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pentobarbital will minimize the extent or influence of voriconazole by affecting hepatic enzyme CYP2C9/ten metabolism. Insignificant/Significance Not known.Barbiturates can induce hepatic microsomal enzymes leading to greater metabolism and lowered anticoagulant response of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocou